Mitosis and Meiosis Activities for Middle School Science

The Kesler Science Mitosis and Meiosis Complete 5E Lesson is a multi-day, engaging resource designed to simplify your lesson planning. It provides everything you need to help students explore essential questions about cell division, such as the similarities and differences between mitosis and meiosis, as well as the phases involved. With minimal prep required, this differentiated, student-centered resource allows teachers to focus on fostering real student success.

Based on the 5E Model, the lesson includes materials for every stage of learning. Students engage with vocabulary and discussion activities, explore concepts through a differentiated, student-led station lab, and deepen their understanding with editable PowerPoints and interactive notebook templates. The lesson also provides opportunities for elaboration through student-choice projects and evaluation with assessments tailored to various learning levels. Multimodal materials—such as hands-on demos, reading passages, videos, and writing prompts—ensure accessibility and engagement for all students.

This flexible resource works seamlessly for in-person and virtual learning environments, with printable and digital formats, Spanish translations, and editable components. Whether used for class discussions, independent work, or as extension activities, this comprehensive lesson supports creativity, collaboration, and mastery of mitosis and meiosis concepts.

Keep your middle school students actively engaged with this modular, student-led station lab on mitosis and meiosis. Designed to support differentiated instruction, the lab encourages students to explore and compare the processes of cell division through a variety of hands-on and digital activities. This flexible, low-prep resource fits easily into your structure of life unit and allows students to learn at their own pace while the teacher acts as a facilitator.

The station lab includes nine interactive stations—four input and four output, plus a bonus challenge station. Input stations expose students to content through videos, readings, web research, and hands-on activities, with materials available in both English and Spanish. Output stations give students creative ways to demonstrate their learning by organizing information, illustrating cell processes, writing responses, and completing assessments using task cards. The Challenge It! station offers extension activities for early finishers through games, puzzles, and mini-projects.

This TEKS-aligned station lab is fully editable and ready for both in-class and virtual learning. All signage, task cards, and instructions are provided for students to work independently or collaboratively. Compatible with PowerPoint and Google Slides, the lab also appears in the Mitosis and Meiosis 5E Lesson Plan, making it a versatile addition to your middle school life science curriculum.

The Kesler Science Mitosis and Meiosis Student Choice Projects offer middle school students the opportunity to select a project that matches their preferred learning and output style. With six engaging project options and a “design your own” choice, students can showcase their understanding in creative and personalized ways. A grading rubric provides flexibility for teacher, peer, or self-assessments.  

The resource includes nine differentiated project options, editable rubrics, and teacher directions to support various student needs. For learners requiring remediation, a modified version simplifies three of the project options, while advanced students can tackle multiple projects for a deeper challenge.  

Designed for ease of use, these projects utilize standard classroom supplies like paper, markers, and scissors, with options for digital completion. The flexibility of this resource allows students to work independently or collaboratively while building their understanding of mitosis and meiosis through hands-on, student-centered learning.  

The Kesler Science Structure of Life Interactive Notebook Bundle provides an engaging way for students to explore life science concepts through interactive activities. Designed for both print and digital use, this resource is perfect for traditional classrooms, 1:1 environments, and distance learning. Topics covered include cell theory, genetics, plant and animal cells, and more, offering a comprehensive tool for teaching the structure of life.  

The digital version includes a unique interactive notebook PowerPoint that can be uploaded to platforms like Google Slides or MS Teams, complete with reflection pages, note spaces, and an answer key. A modified digital version is also provided for students needing accommodations. The paper version features blank and pre-filled templates, along with color photos to guide usage, ensuring all students can participate effectively.  

With resources tailored for diverse learning needs, the Kesler Science Structure of Life Interactive Notebook Bundle supports differentiated instruction and student-centered learning. Teachers gain a versatile tool for enhancing understanding, while students build lasting connections to key life science concepts.